HO-2 has been found to be closely associated with sGC, ALA synthase, cytochrome P450 reductase and NOS in the brain (Wu and Wang, 2005). levels in tissue, e.g., kernicterus. Care must be used to ensure that when these compounds are used as therapeutic agents their deleterious effects are minimized or avoided. On balance, however, the … Continue reading HO-2 has been found to be closely associated with sGC, ALA synthase, cytochrome P450 reductase and NOS in the brain (Wu and Wang, 2005)